Help Heal The Damage

Want to know how you can help?

Jenn of likealilyamongthorns featured these Delia Earrings, part of my Carmella Collection yesterday in her wedding blog, "The Adventures of a modern Housewife". They'll make a wonderful addition to any bride's outfit on that big day!

Read the write-up, and purchase, and or send the link to your frends and help Carmella in the process.
http://amodern-housewife.blogspot.com/2010/03/wedding-wednesday.html

 If you have a wedding or formal occasion coming up I have an intrigueing variety of jewelry pieces that are sure to make your experience one-of-a-kind and extra special! I also take custom orders if you have specific colors or styles in mind for the bride, bridesmaids, and any others who require something you don't already see in my etsy shop; http://Giftbearer.etsy.com

You can also purchase one of the ad slots to your right in my sidebar (click on the link at the bottom for instructions on how) at a cost of $5.00, or donate in any amount with a credit card or Paypal account through Paypal by going to the link that says "Please Donate To Carmella". I still have a long way to go to pay off her medical costs.

I just returned from GA. Veterinary Specialists after a long day. While we were there Carmella was excited at all the other dogs coming and going and whined almost non-stop wishing she could play with each one of them. The building was a large gray stone-looking brick structure with what looked like a cast iron sculpture out front of a tree and boys climbing up it after a cat that was perched on the furthest limb. Surrounding that on two crossing sidewalks were tufts of long ornamental grass growing like tentative topknots in hard-packed soil bogged down slightly by the recent rain.

My friend and I entered through the front entrance with automatic doors and made our way through a series of wooden benches to our left and right up to the reception desk in the center of a large atrium. Carmella could hardly contain herself and pulled almost hard enough to knock me down. It was quite a feat holding onto her leash and signing in, then filling out the preliminary paperwork. Tying her leash to a bench on the right I managed to complete the form and return it to a staff member as she walked by but not before Carmella began dragging the bench part-way across the floor. I caught her just in time and pulled her back. She was intent on making contact with an elderly Golden Retriever who sat nervously on the floor at the adjacent bench her owner was sitting on.

Unsure of Carmella's intentions she wimpered and looked up at the woman who looked back at me a little awkwardly as Carmella shreiked loudly at her dog in malamute-like tones tugging so hard at the leash she nearly choked.

My friend went outside to answer her cell phone and it wasn't long before Carmella and I were called back to wait in a room for the neuro vet. I think it must have been 30-40 minutes before she was ready to see us and in the meantime Carmella had to go to the bathroom, so I took her out front among the sparse tufts of grass. She peed and pooped without much delay and was then ready to go back inside. My friend came out just as we were headed for the front door and we went inside, she in the waitingroom, and Carmella and I to the inner room where we waited for the doctor.

The neuro vet looking to be in her early thirties, slim, with long dark brown hair pulled back in a long ponytail came in soon after trailed by a vet tech and an intern, and shook my hand a little too hard as though to convey something, though I'm not sure exactly what. Something about her seemed too deliberate but she smiled and introduced herself and the intern and asked how Carmella was and inquired about the symptoms that brought her in. Just as I came back into the room I'd heard her discussing Carmella with a man in the next room whom I supposed was Dr. Johnson (the male neuro vet who had refused to do the CSF procedure back before Carmella had started jerking and languished over his decision for weeks while Carmella began developing neuro symptoms that increased by the week). I just caught the tail end of their conversation but I'd heard him say something about Dr. Sears to the female neuro vet. I wondered whether he had told her that he'd refused to treat Carmella 17 or some months ago and why (that it wasn't in the medical literature).

This new vet asked me lots of questions about her myoclonus and any other neuro symptoms, and also asked whether she had any more respiratory symptoms. I thought "why would she now?" Then she did a thorough neuro exam checking her reflexes, looking in her eyes, looking to see whether she responded to sharp objects, etc, as the vet tech and intern looked on. Eyesight was good, reflexes good, other than the leg and the myoclonus all alse checked out. That was the good news. Then came the bad.

She asked me whether Carmella was on any medication for the myoclonus and I told her no she wasn't. She admitted that there wasn't much that would work for myoclonus and that the only thing she knew of that worked enough to really reduce the jerking significantly was a drug called Procaine which she said could have cardiac side effects so the dog needed to have an EKG prior to starting it and that it comes in injectible form or pill form. The pills have to be given 3 times a day.

She went on to say that not much else that she knew of could be done and that myoclonus wouldn't show a lesion on an MRI because any structural changes would be on the cellular level and microscopic if any, and it could be caused by purely electrical disturbances originating from possibly neurotransmitters in the nerve root "or the invironment around it" (where it meets the spinal cord in the shoulder).

She seemed to be extrapolating from what she'd read; things I've also read in medical journals. Her phrasing was "They think it's caused by that". She seemed to be reaching for answers that weren't verifiable by any tangible means like one who has heard a myth passed down by their ancesters and tells it again from old stories one heard as a child, so certain of the truth of this theory through sheer faith, yet so uncertain by any accepted scientific standards of proof. It is one of those theories accepted by the specalty more by default than by reason. She seemed to want to leave it at that and think no further. She said that she didn't "want to biopsy the nerve root"; that "that wouldn't be fair to her" as if to imply that would be the only way to find a focal point.

I mentioned the possibility of a stem cell transplant and she replied that was not being done yet outside a lab and that she couldn't do it. I told her that I didn't think she could but that there are two vets that I know of in town already doing it on dogs and that one in Alpharetta had been on the news just recently. The other was on Hwy. 78. I silently wondered how she could have been totally unaware of this great discovery hitting the market when it's all over the internet now and on the local news. It's even in journals, (but I guess not the ones she reads).

She seemed embarrassed or irritated; one or both by my giving her that information and said she would be really glad if there were a cure, but her words had a hollow ring to them as though she didn't really mean it if she couldn't have known it first.

I had the sense that she was paddling hard trying not to drown in her own cluelessness, covering it up with a guarded and clipped defensive demeanor as the conversation got more specific. Her friendliness quickly faded to a tense and deflective stance in which she resembled a bird perched high atop a way-too-slender limb on the verge of cracking beneath her feet.

She said that the fallen arch in the leg was, as I thought, due to the jerking, and that it probably wouldn't get better but if the jerking was lessened it might prevent it from getting worse. Without controlling or stopping the jerking it would certainly continue to deteriorate. The ligament has been stretched too much; not her specialty she said, but an "orthapedic problem". I asked what could be done about that part of the problem and asked if a splint would work and whether any sort of physical therapy could prevent further damage. She responded by telling me I'd have to ask an orthapedist and a physical therapist. That sounded kind of smart-alecy to me, as she did not recommend any names, just left it at that and stared back at me almost defiantly as if to say, "So there!"

I told her that I really don't know what to do with that information. She continued to flounder.

(I'd assumed they had those specialists there but felt it was futile to ask at that point as she seemed to be taking every one of my valid questions as a personal attack. As she offered no help hooking me up with them I did not want to take another trip out there across town on a maybe). She did sign my insurance form, handed me a card and a one-page typed report, shook my hand hard again, and I checked out and put the papers in my briefcase.

My friend was waiting in the atrium and I told her what happened. She was flabbergasted. that she was just dismissing us like that with no follow-up. I said, "Well at least this documentation will help somewhat when I approach the stem cell transplant vet. It may not need to be pinpointed exactly if she's right that it's coming from the nerve root in the shoulder. Stem cells could probably be put there and they'd migrate directly to where they're needed, and since this is already shown to be successful for ligament regeneration it might help in that spot at the wrist too!"

Perhaps despite her uncooperativeness and lack of preparation this vet had really given an answer anyway although mired in layers of porcupine quills. If she's right that its cause is due to problems with neurotransmitters I don't know whether stem cell transplant fixes that or not. I'll have to do some more reading about that to determine if it would. I still have access to some of the top specialists in that field on the committee I spoke of in one of my earlier posts. They are likely to be a storehouse of information since they are doing alot of research on various stem cell techniques. As I recall some mentioned in their bio that they sub-specialized in neural cell regeneration! Perhaps they will know the missing piece. Armed with that specificity I can then approach the stem cell vet and discuss the best way to go about it.

This dog didn't deserve what happened to her and deserves to be restored to complete health again. Because so many dropped the ball I am now paying to correct the mis-steps they made, as is Carmella.

My goal this year is to sell all my current inventory, help Carmella with the proceeds, and begin to phase in all new pieces! With the community's help I know this can happen! With Love and Action All Things Are Possible.

Carmella Gets Neurological Referral

Today the phone rang. It was Jocelyn from Dr. Norwood's office calling to let me know the paperwork had been completed for Carmella's referral to Ga. Veterinary Specialists. It had been a long time coming and I was relieved that finally we would get to the bottom of the myelin damage causing her constant jerking and atrophy of the leg.

As it turned out transportation was really the biggest barrier because I had only two people I could ask and finances and health problems were preventing one of them from driving more than two trips, and the other one's job prevents her from going until later in the day, and even then only on Thursday and Fridays because she takes work home with her three of 5 days every week.

The policies dictating when GVS does certain things narrowed it down even further, but finally after several hours of vascillation and negotiation we came up with a workable plan and set the date for March 18th at 11:45 AM. Carmella will see  veterinary neurologist that day for an exam and most likely will have to come back another day for the MRI and any other tests.

I spoke on the phone with a very nice woman who told me that although they usually don't do this it's possible that something can be arranged the same day once I get her in there and talk to the vet if the radiology people can fit her in that day. This has taken so long to arrange that it would be nice to get it all out of the way in the same day, especially since I won't be picked up for several more hours after her exam.

Apparently they will put her under general anesthesia during the MRI so that she won't move, and it takes 2-3 hours because the MRIs they use for dogs are less powerful than the ones used for humans so it takes longer to get all the pictures. The neurologist might order other tests and will give me a price quote ahead of time once it's established all the tests she's going to need.

Since the time I called over a year ago when Carmella needed the CSF procedure they have added a new neurologist that used to be an intern and decided to specialize. I was thrilled to hear this, as the other one wasn't very interested in helping Carmella before. I hear this one is very open-minded, so that is who I made the appointment with.

I took some really cute pictures of Carmella tonight. As she often is she was chewing on something in many of them.

For some reason she seemed to be particularly hyper tonight and wanting to chew on my arms. I threw a rubberized dumbell for her to fetch that she'd stripped of the outer surface long ago, and I played tug of war with her for awhile until we both were worn out.

Hopefully she'll sleep well tonight after all that exercise and won't jump off the bed at the crack of dawn as she sometimes does when I'm not awake enough to get up.

This morning was one of those rare days that she stayed curled up beside me until around 12:00 noon. I needed the rest anyway after the long hours I'd worked the day before getting a wedding order completed.

This morning I wasn't feeling so well and needed to stay in bed until the pain in my back, stomach, and legs subsided.

I had also stayed up around the clock one night getting a bunch of my jewelry ready to go to a store. I am going to prepare another batch this month also in hopes that I can make a decent amount of money this month. There will be alot of money to raise given the upcoming medical expenses for Carmella.

I see it is 3:30 in the morning already so I'll get this posted and then get some sleep and promote this entry later on today. If any of you find it in the meantime please feel free to post your comments! If you aren't yet following and you would like to keep up with Carmella's progress please do so. Things should be getting very interesting in the coming weeks and months!

Happy Birthday, Carmella!

Well, time sure has flown! Carmella is 2 years old today. She still looks and behaves much like a puppy, but sure enough she's all grown up.

I took some more beautiful shots of her.

This dog has a real sense of humor, and a presence which is almost human.

Sometimes I wonder whether she understands alot more about what's going on than I even realize.

On Saturday I went with a friend to Dr. Norwood's office when she was taking her dog in and got a chance to ask him whether he'd put in the referral for Carmella's MRI. He'd been sick with the flu that's been going around this winter, but told me he was going to get on it now and that somebody  at the specialty clinic could help pave the way for the MRI and a full neurological work-up.

Tonight while I was taking pictures of her eating she put her right front leg in that position I sometimes see in which her arch flattens almost all the way to the floor. I snapped a picture just before she moved it.

I hope we can get the right people on this to repair the damage. There are at least a few other dogs who could also benefit from this help if we can identify which of the various techniques will be the most effective.

Over the weekend I was reading alot of journal articles about stem cell transplant techniques, and there seem to be several versions currently being used. Luckily for Carmella, many of these are being done currently in dogs or at least are not illegal for use in dogs right now!

One foundation completely devoted to stem cell techniques and technology has put together a team of the top specialists in the world who are on the cutting edge of research in the field. Each of these specialists have their own sub-specialty and focus within stem cell research. Some of them are physicians for humans, and some are PhD level scientists. I plan on contacting some of them to see whether they can help brainstorm and solve Carmella's problem.

I didn't have a gift to give her today, but if we can restore her to the way she was before Distemper uprooted her life, that will be the best birthday present anyone could wish for.

Update on Carmella

On February 12th we had about 4 inches of snow here and I took some beautiful pictures of Carmella in it! She really had a great time running around in it. I'd been meaning to post these for awhile but have been so swamped making new products for my Etsy shop and working on getting Carmella's MRI arranged that I haven't had a chance until today.

I'm waiting for Dr. Norwood to get the necessary paperwork done because the clinic that has the MRI machine requires a referral to get an appointment with them. This MRI is way overdue, as I had wanted to have one done before she was treated for Distemper 16 months ago, then later to see if there was any documented healing of damage that was done to the CNS by the virus.

 Her stem cells have repaired some of the damage on their own (her back left leg) but since this is still new territory it is anybody's guess just how much damage will repair without help and when the endpoint is. Even Dr. Sears doesn't know what to expect. Like man's first walk on the moon, it seems Carmella's journey is a voyage of mystery.

I remain concerned about the awkward way she has had to hold her right, front leg for the past year to balance while it's constantly jerking, and the changes to the wrist that have taken place.

Seeing her run like a jackrabbit across the yard in the snow the other day made me realize just how precious that is and I don't want her to get to the point that she can't do that anymore. It would be a tragedy after all this if atrophy left her even more disabled than when she had Distemper.

In every other way she is healthy and robust.  It is hard to know until we look at the brain and spinal cord whether the problem is all demyelination, whether scar tissue has complicated the neural pathways (or both). I just wish that I had the appointment set up so that we'll have an answer soon. I'm going to call Dr. Norwood again today to see whether the wheels are in motion, and hopefully get that referral done today.

I'm finding it hard to think of anything else even while I'm working on other things. Sales have been at a standstill this month so far and I don't know why. Had I been making better sales her bill could have been paid off by now. I'm looking into the possibility of doing two indoor shows, but they're at least a month or so away, if I can arrange it. I'm also keeping my eyes peeled for new stores to carry my work.

I'm still collecting Carmella's fur for the miniature I'm making of her. I have the wire armature frame made and next I will add the core wool. Here is a picture;

My plan is to make a number of different miniatures of dogs who have been cured of distemper the way Carmella has.

Squirrels have taken up residence in my attic and they wake Carmella up as soon as it gets light outside, squeeking and chasing around above my bedroom like mischievous children with too much time on their hands.

There must be an overpopulation of squirrels in this area, as it almost seems like an infestation!

The first time I heard the noises they made in the attic I thought a nest of birds had hatched up there.

Carmella jumps off my bed about 6 times every morning until I drag myself out of bed to let her out so that I can rest.

More often than not she's more interested in looking out the window in the computer room at the front of the house than going outside, so I have to practically shove her out the door after she plays dead and limp on the livingroom rug. She looks up at me as if she thinks it's funny. I am not amused, trying to lift her up and out while a blast of cold air bursts into the house, her body like a sack of potatoes. It's way too early for these kinds of shennanigans.

All of this usually takes several minutes of coaxing and chasing her from room to room as she tears around the house like a greyhound on the racetrack before I can finally convince her to go outside.

Once out she seems to enjoy the crisp air and she runs over to the side where the neighbors are just getting into their cars to head off for work, barks a few times, then runs back across the expanse of the yard to nose around in the leaves and pinestraw that have dropped from the trees and chewing on fallen branches.

The snow is gone but it was fun while it lasted.

http://Giftbearer.etsy.com

Healing The Damage of Distemper-The Next Leg of the Journey

It's been a year as of October 1st, 2009 since Carmella has had the CSF procedure and though she's done alot of healing it appears that the myoclonus in her right front leg still remains. Generally everything that will heal on its own will have done so after a year.

Her leg has over time become somewhat weakened as though she has a fallen arch and that appears to be from holding it in an awkward position much of the time in an attempt to balance herself. The wrist looks somewhat elongated compared to the other and she holds it up off the ground or even knuckled over the way a primate holds its hand leaning on it on the ground. This is not natural for a dog and I'm worried if left that way could result in further weakening, and atrophy.

Dr. Norwood noticed this too the last time he saw her in the office, and it has continued to worry me. Initially I was looking into the use of Quinine but only found one research paper but then was not able to find it again to give him.

I started thinking about stem cell transplant, as I have heard more and more about this in human spinal cord regeneration. Since Distemper-caused myoclonus generally originates in the brain stem or spinal cord around the shoulder of the dog it occurred to me that maybe if a stem cell transplant could be done on that area that was damaged by the virus Carmella could regenerate new myelin!

When I did a search I found that MS has been particularly challenging for scientists to treat with stem cell replacement because there is a missing link in the technique that would make it more complete for that disease which is not as complex in other diseases and injuries.

MS in humans is closely related to canine distemper in much of its biochemistry, but my hope is that the reason MS is so tricky to treat with stem cell replacement is that research has been done on non-cured patients, whereas Carmella no longer has active distemper (so the damage , I believe, would more closely approximate a regular spinal cord injury).

I'm thinking she may need an MRI to find out exactly where the damage exists and whether it's just one small area or whether it's more than one.

I found this company that offers stem cell harvesting from the dog and preparation for transplant; http://www.vet-stem.com/

They mostly mention things like ligaments, but I found alot online about the possibility of CNS applications for it, so I think this just might work!

Carmella does not look very comfortable having to live with the constant jerking and a leg that seems like it might or might not support her weight at any given time, and at times her wrist nearly lies flat on he ground when she doesn't hold it knuckled over, looking more like a hoof sometimes than a paw, so if I can get this for her, and it works I'll be thrilled.

If Carmella's experience proves successful this will provide alot of hope to other dogs out there who did not get the Distemper treatment soon enough to prevent this sort of permanent damage!