Showing posts with label brain. Show all posts
Showing posts with label brain. Show all posts

Monday, October 13, 2008

Document, Document, Document


Now that Carmella is beginning her recovery stage I've been giving some thought to what needs to be done to document her improvement for the medical journal article to come. I am so excited that Carmella is going to be a part of saving other dogs' lives and want us to do this right so that her case history will be taken seriously by the vets who will be on the review panel of whichever journals it will be submitted to, and vets in practice, after publication.

We're still trying to locate a lab in the US that can test the strain of Distemper in her spinal fluid. The portion for that test is still sitting in Dr. Muller's refrigerator or freezer while we try to work out the logistics. Luckily frozen it can stay viable indefinitely.

I spoke with the pathology lab at UGA and got a much better reception there than we had in the clinical section earlier. There happened to be a vet there who has spent most of his career studying Distemper and he was quite interested when I told him about Carmella and the treatment she had. Although he didn't know anyone but the same Italian source I had who tests for the strain, he seems to have relationships with several major Veterinary research centers around the country and he may be instrumental in pitching this treatment to them, which in turn could get somebody interested in doing clinical trials. I gave him Dr. Sears' e-mail and the link to his dog-based serum and we exchanged e-mail addresses.

He was unaware that the CDC had Canine Distemper on their list of Bioterrorist agents or that they'd documented 13 seperate strains, and was a little shocked, stating that they are mainly an agency for humans and that Distemper can't be caught by humans. I said that was my understanding too, but I have always wondered why they had that on a bioterrorist list. Who knows, maybe it was about potential threat to our food supply, not directly to us. I'm not sure if cows and chickens catch it or not.

Then I called The University of Tennessee. It took a few calls back and forth to reach the right person, but a woman vet called me back from their imunology lab and told me that they don't do the test there either but that she'd try to help me find a lab that did and that I should hear from her tomorrow. She thought she remembered something being done along those lines in Colorado. I hope she does have a good lead there because that would be much cheaper than sending it all the way to Italy!

This blog will keep an important record of Carmella's progress, but I have been thinking also that in addition to the other tests Dr. Norwood and I spoke of the other day maybe she should have regular MRIs to show any changes in her white matter that is damaged by the disease, causing the jerking. If brain and nerve tissue can be regenerated then advanced imaging techniques such as MRI could really show dramatic improvement, and one thing about pictures is they are hard to dispute.

Carmella was bursting with energy today. I think she felt better than I did as the first half of the day I was feeling very groggy, had junk draining down the back of my throat, a headache, and my stumache was churned up. I had this achey, itchy feeling too throughout my body. I needed to stay in bed to get that under control and Carmella was especially feisty and kept wanting to go out of the kitchen.

She was chewing on me again as though she had such an insatiable urge to chew that her toys and sticks weren't enough. My bare feet seemed to be a magnet for her needle-sharp teeth. Sometimes she reminds me of a shark always with her mouth open looking for some flesh to bite into.

I went out several times with her into the back yard and threw sticks for her to fetch. Eventually she grew bored with that and set her sights on chomping into an arm, hand, or leg.

She seemed to have lost her chew stick that she'd been working on for the past month, so I got out another one for her and she set about breaking it in.

That baby bird smell is gone now. It seemed to last just about 2 1/2 months. Too bad because it was a nice smell. She doesn't smell bad now, but the baby bird smell was especially sweet.

The necklace donated by Tracey sold on Ebay on Sunday night for $22.00, and another donation came in via the blog donation button yesterday too. I sent off another payment today toward the vet bill.

Those of you thinking of doing some advertising, don't forget you can purchase ad space on my blog for only $5.00. Those little banners stay there until they bump one by one off the list, and there are lots of slots left to be filled.

The woman from the rubber stamp company got back to me and I sent her the specs I wanted to see some of my pictures in round and some in square or rectangular shapes.

I'm really looking forward to getting started on my new line.

In addition to the pictorial fine silver jewelry I'm planning with Carmella on it and some other scenes I found some really neat seedpods on a tree over the weekend that are going to be covered in fine silver and made into jewelry as well. They are great for Halloween, as they look like lanterns or gourds of some sort. Their natural color is a kind of burnt sienna or burnt umber which I think I will try to re-create with liver of sulfer when I put on the patina at the end.

Tuesday, September 30, 2008

A Little Panic For A Moment but We're Ready


This afternoon I was tying up alot of loose ends and taking more pictures of Carmella when I decided it might be educational to show on my blog what NDV looks like, so I opened my refrigerator and held it up to the light and took a picture of that and another of the dillutant that goes with it.


Everything was going smoothly when I got down to cropping and editing my pictures and when I came to that one as I cropped it and showed it to "fit on screen" I saw the magnified tiny lettering below the title and it said B1, not LaSota strain. I freaked out because this was why the procedure was rescheduled the first time, thinking that would not work, but this time it was too late.

I rushed around writing e-mails to Dr. Sears and Dr. Norwood in a panic asking if they knew whether this strain would do the same job or whether it would hurt her if it was not LaSota strain. Being around 6:30 pm Dr. Norwood was already gone and I figured I may or may not hear from Dr. Sears in time unless he checks his e-mail in the evening. I waited until around 9:00 pm and kept checking and since tomorrow when I got up would probably really be the crack of dawn for him I figured I better call him.

He answered the phone and I told him the predicament. Luckily he said it would still work and that as long as it did not have other viruses mixed with it there would be no risk of a reaction. I took a magnifyer and looked at the little bottle very carefully. There were no other names on it, so we should be OK.

Dr. Sears told me that we should not expect the fast kind of recovery that we saw in the body to take place in the CNS, and that for the kinds of symptoms due to demyelination that Carmella has we should not expect to see noticeable improvement for a minimum of 4-6 months. He said that's how long it takes for the regeneration of myelin and new pathways to be created via stem cells. This in and of itself is exciting because in documents written earlier he is conservative on the prospect of regeneration but focused more on the heading-off of further damage, although it is alluded to in certain paragraphs.

He asked me to stay in touch and I said I would. I was too nervous to stay on the phone for very long.

As an aside; it is uncanny that the theme of regeneration keeps showing up in my life.

Both Carmella and I have been nervous as hell this evening. Everytime I go into the kitchen she wants to chew on me. I tried getting her to eat as much as she could earlier because after 10:00 pm she is not supposed to eat anything and she can just have a little water. I need to take her outside on a leash tonight before I got to bed and in the morning because she will eat anything she can get off the ground, even sticks or dirt if I don't stop her.

Tonight I put together a folder with her medical records, the protocol procedure, and other related papers and took out all the stuff from it that would not be pertinent.

Watching the news coverage of the gas shortage I am still a little nervous about taking a taxi in the morning, as the forecast is that lines are shorter but many stations are still running out. I hope there are enough drivers working tomorrow so that they are not too backed up. I plan to call at 7:00 (two hours before we need to be there) just in case.

I also wish that a friend could sit with me while I'm waiting in the waitingroom to see how the surgery comes out. It feels alot like when my son was in the hospital being evaluated for brain surgery. I was pretty much handling it alone.

Well pretty soon the hard part will be over, the last shreds of the virus will be gone, and Carmella will be out of the woods. I'll be glad when she is home, safe and sound.