Apparently they will put her under general anesthesia during the MRI so that she won't move, and it takes 2-3 hours because the MRIs they use for dogs are less powerful than the ones used for humans so it takes longer to get all the pictures. The neurologist might order other tests and will give me a price quote ahead of time once it's established all the tests she's going to need.
Thursday, March 11, 2010
Apparently they will put her under general anesthesia during the MRI so that she won't move, and it takes 2-3 hours because the MRIs they use for dogs are less powerful than the ones used for humans so it takes longer to get all the pictures. The neurologist might order other tests and will give me a price quote ahead of time once it's established all the tests she's going to need.
Friday, August 29, 2008
Yesterday was a mix of joy and agony. Our plight continues to find the vet who can and will treat Carmella's Central Nervous System.

Once we'd been put in a room, the female vet tech came in (I can't remember her name, but she is the best one). She asked me if I had had any luck with Dr. Brantly doing the procedure and I said that I thought he was going to do it, but he changed his mind, but that we're still looking. She understood the ramifications of all this, and although happy with the results in the body, knew she was not through yet with what needed to be done in order for the cure to be complete. She commented to another assistant standing in the doorway that this dog was a miracle, beaming from ear to ear.
Dr. Norwood came in and started checking Carmella's reflexes, looked into her eyes, and saw her walk down the hall. She did pretty well, but stumbled at the end once when coming back to the room.
Carmella was in almost constant motion and we had to get her to calm down before he would see the jerking. Eventually she stayed still enough that it started up again and he definitely saw it.
He told me that he'd had no luck with Tuskegee, and was getting pessimistic about whether any of these Universities would help unless they were already doing studies on Distemper. He was still very mousey about calling them and said he'd do it but it could turn out to be another dead end and he couldn't promise anything.
"Like with Dr. Johnson, I can't make them do it."
"Well just make an empassioned plea, show them all that you've documented about her success from the NDV in the body, and advocate as if it were your own mother who was sick and needed treatment."
At this point there were no other real prospects on the table, so I figured this had at least as much chance as anything we've already tried. Up until now we'd just been approaching private practice vets. If this is still considered "experimental" then so be it; we'd just take her somewhere where they do experimental work. Seeing as that UGA is considered one of the best veterinary schools in the Southeast, they should be able to handle this. We just need to get them to try.
Dr. Norwood seemed to be angling at cutting our losses and just going with the partial cure (what we'd gotten in the body).
"The myoclonis could be permanent damage to the myelin and white matter, just residual effects of the disease."
"If that were the case then it wouldn't be increasing over time."
"We could give her Klonazapam, a veterinary version of an anti-seizure drug used in humans." I already knew what it was. Both myself and my son had taken it in the past for our seizures.
"The point is, that if the virus got into the CNS, which it would have to in order to cause that damage, then being in such an enclosed area it would still be present. To assume it's no longer there would just be guessing".
Dr. Norwood was rationalizing to make all the rejections by all the vets we'd appraoched easier to swallow. Maybe for him it would be easier to tell himself that the job was complete, but the idea of leaving this to the imagination and then ending up with worse problems down the road because we made the wrong assumption didn't sit well with me and it didn't make sense based on the biochemistry of the disease.
The CNS is a veritable fortress, and with good reason. It protects the most vital part of the body, the brain; the control tower on which all other function depends. An infection with the deadly Distemper virus is not something you want to leave sealed up for eternity in a dog's head, on a gamble that it will have mercy and not do any further damage. You can hide from it, reframe it, pretend it's not there, and remove yourself from watching its ravages, but it doesn't change the truth. Either it's there or its not. Once it gets in it doesn't just decide its had enough and go away. It's stuck in there and can adapt, hide, and mutate. It gets in via the lungs by piggybacking onto cells that already are able to cross the blood-brain barrier, but it cannot leave the same way it came.
By the end, Dr. Norwood had to admit that the only way to isolate and be sure to eradicate the virus would be to do a spinal tap. He said that UGA would want to do their own tests and probably wouldn't accept his, and it would involve spending more money. I replied that if they ended up doing the procedure then it would be worth it, and besides, if she does have permanent damage the neuro vets there would be the ones to do imaging tests to find any lesions that are there and assess the extent of the damage. If we want to weed out what is damage and what is active disease that's the way to do it.
Dr. Norwood agreed to try again to call UGA's referral coordinator the next day but had been unable to get through the day I came in.
I was up until around 5:00 AM this morning and was too desolate to post an update, and my muscles were starting to ache so I went to bed.
Dr. Norwood was in with a patient when I called this afternoon. Gwen, the office manager took a message that I was asking about the referral to UGA and said she'd have him call back, but he didn't.
I hope he's not wimping out when we need his support the most. When it's all done there will be time to celebrate, congratulate and let our guard down, but until then we are still on high alert. Failure is not an option. Carmella's life may depend upon our level of endurance and ability to go the full nine yards. Perhaps UGA's symbol; the Bulldog, should be our guiding example.
http://Giftbearer.etsy.com/
Tuesday, August 26, 2008





Monday, August 25, 2008
"He's tried and tried to publish, but they won't let him in", I said. "You can talk to him yourself. I have his number and e-mail address."




I adopted a puppy from an animal shelter that I named Carmella, and she turned out to have Distemper. I looked far and wide to find out the best treatment available and came across Dr. Alson Sears’ protocol using Newcastle Disease Virus Vaccine (the LaSota strain) off-label, which is as far as I know the only thing that has really eradicated the virus successfully in dogs. My regular vet tried it on her (an IV to treat the virus in the body) and it worked quite well. When she was first diagnosed they didn’t know if she’d even make it through the weekend, but the treatment really brought her back! The only problem is that she also needs to have it injected into the spinal area, the Foramen Magnum, because it does not cross the blood-brain barrier when injected in the body. Her Central Nervous System is still infected, and although she is dramatically better in every other way, her neuro symptoms are gradually getting worse. My vet has never done a spinal tap before, so although he would do it if he had the skills he does not feel qualified. I have had a hard time finding a vet who is both qualified and willing to do this, and it appears that there are only two board certified neuro vets in Atlanta (and about 4 listed in Athens).
It is a real shame that the medical journals up till now have refused publishing Dr. Sears’ papers on this discovery, and I really think an academic institution should step in and do clinical trials on this treatment and begin to document and publish findings on its effectiveness. As of yet I have not been able to find anybody but Dr. Sears even attempting to look for a cure for distemper. I looked through PubMed the other night for several hours and although there are studies that circumstantially hint that this could work, most of the studies are aimed at testing better vaccines to prevent; not cure the disease. Somebody should be very interested in this, as I have pictures showing that after the initial shot by IV Carmella’s pads completely healed within just about 2 weeks after injection with NDV. This bird-based vaccine, mostly used in the poultry industry is manufactured by Merial right here in Georgia, and Dr. Sears has a formula that is a dog-based serum which he has given people permission to post online and to use to treat infected dogs. One vet I have spoken with tells me that he knows a vet in Alabama who uses the dog-based serum regularly in the body and reports great results with it. This is good, but these dogs need vets who are willing to test and treat in the Central Nervous System as well, and the most likely candidates to take on this challenge are neuro vets with an interest in research.
Maybe Merial would fund a study if you put in an application. It’s something to seriously consider. They seem to have done a fair amount on Distemper and may be very interested if their product could be proven to kill the virus; not just be used as a vaccine to prevent it. It might be worth testing both the NDV and dog-based formula. Publishing something would remove it from the virtual no-man’s land it currently sits in, and could be of great benefit to science and to Veterinary Medicine, not to mention having the potential to make a significant dent in the epidemics in shelters which probably cost billions of dollars nationwide.
It seems that given Carmella’s success with the first injection that as long as she gets this early enough she should have a good prognosis with the spinal injection as well. If ever there was a good candidate for a successful outcome it is her. Her secondary pneumonia is almost gone after several weeks of antibiotics (2 weeks of that with Azithromyacin), and she is otherwise healthy. Her weight is back up, and she is eating and drinking well. She has boundless energy, (unlike before the first shot when she was lethargic). She should be able to withstand anesthesia. I don’t want to wait until the symptoms are too extreme because then it might be too late to prevent permanent damage from the Distemper virus.

Currently she has mild to moderate chorea in the right front leg and sometimes shoulder which happens intermittently. So far it has not affected her activity overall and happens mostly when she’s at rest. In addition she has an occasional moment of clumsiness, but so far no seizures or overt paralysis. Even so, over the past day or so I’ve noticed a gradual worsening and this morning her right front leg was jerking perceptibly even while she was standing on it while I took her out for a walk and she had to lift her paw on a few occasions. (Some of the vets I’ve spoken with in recent weeks took the position that “maybe” it won’t progress but I think that ship has already sailed).
I hope you can help her, as I’ve run out of people to ask in the Atlanta area and I don’t know how much time we have before she gets even worse. She is a beautiful, loving dog and I want to do everything I can to save her.
If you’d like to speak with Dr. Sears to find out more about this treatment he developed I have two phone numbers for him and an e-mail address; (phone numbers removed from public view), and e-mail: AntiDistemper@aol.com
He and I have been in contact for a few weeks now. He is willing to speak with any vet I work with on this.
Please contact me as soon as possible. It would be a big load off my mind if you will do this. Carmella deserves this chance. She is a very special dog, and not only to me. When you meet her in person you will know what I mean.
Sincerely,
Pippit Carlington

Thursday, August 21, 2008
Chicken...Buck Buck Buck!
And I'm Not Talking About What's In The NDV Vaccine
Dr. Brantly came sheepishly to the phone this afternoon, intent upon making his point, and with voice quivering he said, "Hello? Ms. Carlington? Are you calling about Bear?"
"Oh, yes, Carmella." The doctor seemed to snap his mind back into focus.
"So, have you had a conversation with Dr. Sears yet?"
"Well according to Dr. Sears she will be sooner or later even if she's not going to die immediately. I'd rather she not die at all until she would normally. I don't want her to continue to get worse and then have a lingering horrible, and certain death in which she suffers."
"Yes, it's possible. Some dogs have static symptoms like seizures or jerking and still do quite well."

"And you're saying that antibody tests show that those dogs have killed the virus; that it's no longer detectible?" I had him there.
"I'm not sure what you're mainly worried about. Is it doing the spinal tap or the injection? Are you worried that you might hit the chord and paralyze her?"
"You're worried about the preservatives they use being harmful?"
"Yes".
"Yes, but I still don't feel comfortable doing it. It's still too experimental". The last desperate defense of a man who had no defense. So is everything, I thought, until it becomes commonly used. What kind of logic was that, I wondered. Certainly not scientific. If all the techniques used now in other deadly diseases had been simply tabled indefinitely because they were "experimental" chances are we'd be an endangered species by now, and so would our dogs.

"Merial seems to be quite interested in Distemper. They had links all over Google as I was reading last night, and people who own ferrets seemed to be a strong advocacy group for that sort of research. I didn't find as much in dogs, but what if some vets were to team up and submit a funding request to Merial for grant money to do a clinical trial? It seems to me that would put alot of this fear to rest, and once an offocially recognized study were done vets could stop freaking out about it. If there is real merit to this and it is the only real cure for Distemper don't you think it deserves a chance?"
"Yes, that is a good idea, but it would probably be the academics; neuro vets with the big credentials; those in research facilities who would be the best ones to submit a proposal. Places like UGA have all the equipment, MRI, CT, and contrast for guided imaging."
"Yes, or ones in private practice specialty clinics like Dr. Johnson."
We left it that I would send him any relevant research that implied this would be safe and effective, and that he'd call me to let me know if he thought of anybody who did feel comfortable doing the procedure, and he asked me to let him know if Carmella got any worse.
When he and I got off the phone we both knew the unspoken truth; that he could not scientifically guarantee me that she wouldn't.

When I checked my e-mail there was a message from Dr. Sears.
Regarding the trouble I've been having finding a vet to commit to this procedure, (I had to leave a few choice statements out in the interest of decorum, LOL, so as not to alienate other vets who might end up being important allies), but I can include some of it.
Hopefully yours is next.
Doc Sears"

Carmella still needs your help. Her bill is growing. Your purchase from my Etsy store is much appreciated. I'd like to thank the few individuals who have recently bought jewelry in the last 2-3 weeks. I just tonight added a new pair of earrings to my Carmella Collection. Remember that with love and action, all things are possible!

Carmella Collection- Lillies of the Valley (earrings)










